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PHD Defense by Malene Brohus

Malene Brohus, Department of Chemistry and Bioscience will defend her thesis on: "The arrhythmogenic Calmodulin Interactome - Elucidation of Molecular Mechanisms"

Time

26.04.2018 kl. 10.00 - 26.04.2018 kl. 14.00

Description

TITLE:

"The arrhythmogenic Calmodulin Interactome - Elucidation of Molecular Mechanisms"

ABSTRACT:

Calcium (Ca2+) serves as a universal secondary messenger by conveying many physiological responses that are fundamental to specific cell functions. The primary eukaryotic Ca2+ sensor calmodulin (CaM) serves to decode such Ca2+-signals. To fulfill the role as a universal Ca2+-sensor, CaM must operate in a rapid and precise manner over a wide range of Ca2+ concentrations. In addition, CaM must be able to pass on information to activate or deactivate a diverse collection of cellular targets.

The importance of CaM is underlined by the three human genes that encode an identical protein sequence which in addition is 100% conserved among vertebrates. Furthermore, CaM is ubiquitously expressed, confirming its Ca2+-sensing role in virtually all human tissues.

Despite the cellular versatility of CaM, mutations in this archetypal Ca2+-sensor are associated with clinical phenotypes that are limited to cardiac arrhythmias. These arrhythmia-causing CaM mutations are associated with dysregulated ion transport through several cardiac ion channels, but the underlying molecular mechanisms remain unclear.

The work presented in this thesis aims to elucidate the interactions between CaM or arrhythmic CaM mutants and three essential Ca2+ channels: the cardiac voltage-gated Ca2+ channel, CaV1.2, the cardiac ryanodine receptor, RyR2, and the type 1 inositol 1,4,5-trisphosphate receptor, IP3R1.

SUPERVISOR:

  • Professor Michael Toft Overgaard, AAU

ASSESSMENT COMMITTEE:

  • Lars Haastrup, Section of Biotechnology, Dept. Chemistry and Bioscience, AAU, Denmark
  • Jan B. Parys, Ph.D. Professor of Physiology. Head, Laboratory of Molecular and Cellular Signaling. Dept. Cellular and Molecular Medicine & Leuven Kanker Instituut, Campus Gasthuisberg O&N1, Belgium. 
  • Bente Vilsen, PhD, Professor. Aarhus University, Department of Biomedicine, Denmark

AFTER THE DEFENSE A SMALL RECEPTION WILL BE HELD AT FREDRIK BAJERS VEJ 7H. 

Price

Free

Host

Department of Chemistry and Bioscience, AAU, Section of Biotechnology

Address

Fredrik Bajers Vej 7H, 9220 Aalborg Ø, room number: 1.102-6

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