Making Proteomics Clinical
From monitoring the health status of preemies to tackling neurodegeneration in the elderly
30.04.2019 kl. 09.30 - 10.30
Please join us for a lecture by Hanno Steen, Ph.D., Associate Professor, Dept. of Pathology, Harvard Medical School, Boston, MA.
All interested parties are welcome. Registration is not required.
For 2 decades proteomics has promised a revolution in biomarker discovery. While there have been numerous studies describing newly discovered biomarkers, few have become approved for diagnostics. Arguably instrumentation and methodology has only now become sufficiently advanced to realize proteomics-based biomarker discovery in practice. The significant interpersonal variability, that affects biomarker discovery by adding a considerable amount of noise, makes it necessary to significantly increase the throughput of proteomics experiments when using primary human specimens. This talk describes a new clinical proteomics platform featuring novel 96-well plate-based sample preparation and data acquisition methods to enable the throughput needed for meaningful biomarker discovery. Example applications range from urine proteomics studies compatible with minuscule urine samples from preemies in the neonatal intensive care unit to neuroproteomics on brain specimens from patients with various forms of neurodegeneration, which lead to a new diagnostic paradigm and resulted in the identification of potential targets for immunotherapeutic strategies against e.g. Alzheimer’s disease.
09:30: Welcome and introduction by Tue Bjerg Bennike
09:35: Lecture by Hanno Steen
10:20: Q & A
About the lecturer
Hanno Steen, Ph.D., Associate Professor, Dept. of Pathology, Harvard Medical School, Boston, MA
- Director of Proteomics, Dept. of Pathology, Boston Children’s Hospital, Boston, MA
- Member, Precisions Vaccine Program, Division of Infectious Diseases and Neurobiology Program, Boston Children’s Hospital, Boston, MA
Free of charge
Department of Health Science and Technology
Fredrik Bajers Vej 7A/B (auditorium B3-104)