Research

Ph.d. defense Munsoor Hanifa

Munsoor Hanifa, Department of Chemistry and Bioscience will defend his thesis on: "NMR-based metabolomics in kidney and lung disease”.

Time

22.09.2020 kl. 09.00 - 12.00

Description

Time and date

22.09.2020 kl. 9.00 - 12.00

TITLE

NMR-based metabolomics in kidney and lung disease

Abstract

Chronic kidney disease (CKD) is a growing problem across the world, mainly due to increasing rates of high blood pressure and diabetes. Acute respiratory distress syndrome (ARDS) is a serious problem affecting the lungs, especially in the intensive care unit, and is caused by a wide variety of triggering factors. Although very different, both illnesses share diagnostic problems which can lead to delays in diagnosis. These delays can, in turn, delay interventions which could change the course of the disease.

Metabolomics is one of the 'omics' fields, where modern analytical methods allow for the measurement of multiple metabolites simultaneously, and in combination with multivariate data analysis, can identify metabolites significantly affected by a disease. In this work, nuclear magnetic resonance spectroscopy (NMR) -based metabolomics was used to investigate CKD, by comparing a rat model of CKD to sham-operated rats, and ARDS, by investigating patients with low blood oxygen levels (hypoxaemia) after cardiac surgery with cardiopulmonary bypass.

Significant findings suggest that oxidative stress and energy metabolites are affected in both illnesses. In CKD, the gut-kidney axis and acid-base balance also seem to be affected, whilst in post-operative hypoxaemia, inflammation and the stress response could explain some of the metabolite changes. Complicated interactions between metabolites and metabolite pathways, and underlying methodological issues, mean that results need to be investigated further and validated using larger groups and different methods.

SUPERVISORS

  • Professor Reinhard Wimmer, Dept. Chemistry and Bioscience, AAU, Denmark

Co-supervisors

  • Dr. Troels Ring, Department of Biomedicine, Aarhus University and The Center for Critical Care Nephrology, University of Pittsburgh
  • Professor Bodil Steen Rasmussen, Department of Clinical Medicine, Aalborg University and Department of Anesthesia and Intensive Care Medicine, Aalborg University Hospital

ASSESSMENT COMMITTEE

  • Associate professor Anders Olsen (Chairman), Dept. of Chemistry and Bioscience, AAU, Denmark
  • Associate Professor Anders Öhman, Department of Integrative Medical Biology, Umeå University, Sweden
  • Associate Professor Christoffer Laustsen, Department of Clinical Medicine, Aarhus University, Denmark
  • Professor Kåre Lehmann Nielsen (Moderator), Dept. of Chemistry and Bioscience, AAU, Denmark

REgistration

Participation is free of charge. Due to the limited number of places in the auditorium, only online participation will be possible.

The defense is transmitted on Zoom. To join the Zoom Meeting, use:

Zoom meeting

Meeting ID: 612 0952 9325

Passcode: 170021

Price

Free

Host

Department of Chemistry and Bioscience, AAU, Section of Biology and Environmental Science

Address

Fredrik Bajers Vej 7H, 9220 Aalborg Ø, room number: 3.122-3.128

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