Research

PhD defense, Boris Modrau

The Department of Clinical Medicine, Aalborg University and Aalborg University Hospital are pleased to invite to PhD defense by Boris Modrau, Department of Neurology, who will defend the thesis entitled: Neuroprotective effect of theophylline in acute ischemic stroke

Time

23.04.2021 kl. 13.00 - 16.00

Description

The PhD defense will take place

Friday 23rd April 2021 at 13:00 pm (CET)

Due to COVID-19, the PhD defense will be held online

Please sign up by e-mail to:inst.klinisk.phd@dcm.aau.dk.

 

Supervisors

Henrik Vorum
Clinical Professor, MD, Dr.Med.Sci., PhD
Department of Clinical Medicine, Aalborg University
Aalborg University Hospital, Denmark                               

Grethe Andersen

Professor, MD, Dr.Med.Sci., PhD
Aarhus University Hospital, Denmark

Flemming Winther Bach
Professor, MD, Dr.Med.Sci., PhD
Aarhus University Hospital, Denmark

 

Assessment Committee     

Carsten Reidies Bjarkam (chairman)
Clinical Professor MD, Dr.Med.Sci
Aalborg University, Denmark

Christina Rostrup Kruuse
Professor, MD, Dr.Med.Sci., PhD
Herlev/Gentofte Hospital, Denmark

Bo Norrving
Professor, MD, PhD, FESO, FAHA
Lund University, Sweden

 

About the PhD thesis

The concept of using theophylline as a neuroprotective agent in patients with stroke began in the 1940´s. Theophylline was used for this purpose widely in the 1960´s-1970´s, but its use was stopped in the early 1980´s due to a lack of evidence about its clinical effectiveness.

The aim of this thesis was to address the shortcomings of previous clinical trials and to evaluate the neuroprotective effect of theophylline in patients with acute ischemic stroke. This led to the Theophylline in Acute Ischemic Stroke (TEA-Stroke) trial, a randomized controlled trial to evaluate the safety and efficiency of theophylline, as an add-on to thrombolytic therapy, in patients with acute ischemic stroke. The trial design incorporates two sub-studies: one used a machine learning approach to assess the neuroprotective effect of theophylline on infarct volume growth, and the other involved a voxel-by-voxel-based evaluation of the effect of theophylline on cerebral perfusion in the penumbra and the infarct core.

The TEA-Stroke trial was conducted at Aalborg University Hospital in cooperation with: Aarhus University Hospital; the Centre of Functionally Integrative Neuroscience, Aarhus University; University Medical Center Hamburg-Eppendorf, Germany; Stanford University, Palo Alto, CA, USA; and the University of Calgary, Canada.

 

Host

Department of Clinical Medicine, Aalborg University

Address

Online via Zoom

Registration Deadline

22.04.2021 kl. 13.00

Register at

inst.klinisk.phd@dcm.aau.dk.

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