Research

PhD defense, Louise Kuhlmann Asferg

The Department of Clinical Medicine, Aalborg University and Aalborg University Hospital are pleased to invite to PhD defense by MD, Louise Kuhlmann Asferg, who will defend the thesis entitled: Pain in patients with chronic pancreatitis - Assessment and association with clinical factors

Time

17.06.2021 kl. 13.00 - 16.00

Description

The PhD defense will take place

Thursday June 17th, 2021
Time: 13:00
Place: Auditorium Syd, Aalborg University Hospital Syd

Please be aware that attending requires that you are fully vaccinated or have a negative corona-test

After the defense there will be held a reception. All are welcome.

 

Supervisors

Professor Asbjørn Mohr Drewes, MD, PhD
Deparment of Clinical Medicine, Aalborg University
Department of Hepatology & Gastroenterology, Aalborg University Hospital

Professor Søren Schou Olesen, MD, PhD
Deparment of Clinical Medicine, Aalborg University
Department of Hepatology & Gastroenterology, Aalborg University Hospital

Ass. Professor Tine Maria Hansen, MSc, PhD

Deparment of Clinical Medicine, Aalborg University
Department of Radiology, Aalborg University Hospital

Assessment Committee

Professor Per Hansson, MD, PhD
Department of Rehab. Med., Karolinska Institutet, Sverige

Professor Jonas Rosendahl, MD, PhD
Clinic for Internal Medicine, Martin-Luther University, Germany

Ass. Professor Inge Thomsen Bernstein, MD, PhD (chair)
Deparment of Clinical Medicine, Aalborg University
Department of Surgery, Aalborg University Hospital, Denmark

 

About the PhD thesis

Chronic pancreatitis (CP) is a fibro-inflammatory disease with progressive, irreversible damage to the glandular tissue, in time leading to endocrine and exocrine insufficiency. Many CP patients are affected by chronic abdominal pain. Assessment of pancreatic pain is typically based on non-validated questionnaires or questionnaires developed for other types of chronic pain. Research suggests that a detailed characterization of pain can lead to mechanism-based treatment algorithms, but thorough groundwork must be performed in order for the algorithm to be able to work sufficiently.


In this thesis a narrative review provides the theoretical background for a mechanism-based treatment strategy including an example of a flow-chart for choice of treatment.


In addition to the review, the thesis includes three original manuscripts. The first manuscript evaluates the clinical factors associated with pancreatic pain to enable choice of interventional focus in treatment strategies.

In the second manuscript a bed-side method for neurophysiological pain evaluation is developed the evaluation show that pain processing in CP     diverges from healthy volunteers and specific defective pain mechanisms, especially    conditioned pain modulation, was related to clinical pain          intensity.

The third manuscript describes the development, validation and reliability testing of a feasible short form of the recently developed pain assessment tool for CP (COMPAT).


In conclusion, this thesis provides the basis for detailed characterization of pancreatic pain, which can be used in clinical practice and research.

Host

Department of Clinical Medicine, Aalborg University

Address

Aalborg University Hospital, Syd. Hobrovej 18-22, 9000 Aalborg

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