Research

PhD defense by Andreas Kiesby Øvlisen

The Department of Clinical Medicine, Aalborg University and Aalborg University Hospital are pleased to invite to PhD defense by Andreas Kiesbye Øvlisen, who will defend the thesis entitled: Socioeconomic Impact of Lymphoma with Focus on Fertility and Mental Health Using Danish Nationwide Registers

Time

03.12.2021 kl. 11.00 - 14.00

Description

The PhD defense will take place

Friday the 3rd of December, 2021at 11:00
Auditorium A, Forskningens Hus, Aalborg University Hospital
Sdr. Skovvej 15, 9000 Aalborg

The defense can also be followed online by zoom:
https://aaudk.zoom.us/j/69091683604

 

Supervisors

Professor Tarec C. El-Galaly, MD, DMSc, Department of Clinical Medicine, Aalborg University, and Department of Hematology, Aalborg University Hospital, Aalborg Denmark

Professor Marianne T. Severinsen, MD, PhD, Department of Clinical Medicine, Aalborg University and Department of Hematology, Aalborg University Hospital, Aalborg, Denmark

Associate Prof. Lasse H. Jakobsen, PhD, Department of Clinical Medicine, Aalborg University, and Department of Hematology, Aalborg University Hospital, Aalborg, Denmark

Associate Prof. Kristian H. Kragholm, MD, PhD, Unit of Epidemiology and Biostatistics and Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark

Professor Martin Bøgsted, PhD, Department of Clinical Medicine. Aalborg University, and Department of Hematology, Aalborg University Hospital, Aalborg, Denmark


Assessment Committee

Associate Prof. Salome Kristensen, MD, PhD (Chair), Department of Clinical Medicine. Aalborg University, and Department of Rheumatology. Aalborg University Hospital, Aalborg, Denmark

Professor Christen Bertel Lykkegaard Andersen, MD, DMSc, PhD, Department of Hematology Rigshospitalet, and Section of General Practice, Department of Public Health, University of Copenhagen, Copenhagen, Denmark

Dr. Graham P Collins, MD, PhD, Oxford Cancer and Haematology Centre, Churchill Hospital, Oxford University Hospital NHS Trust Oxford, United Kingdom

 

About the PhD thesis

This PhD thesis covers the work performed by Andreas Kiesbye Øvlisen from October 2018 to September 2021 at the Department of Clinical Medicine, Aalborg University, and Department of Hematology, Aalborg University Hospital.

The aim of this PhD thesis was to provide hematologists with data that identify focal points for improving survivorship, including identifying patients who may benefit from more social support with focus on mental health problems and fertility in lymphoma patients. The PhD thesis consists of three epidemiological, population-based, matched cohort studies.

Study I showed that Hodgkin lymphoma (HL) patients have a higher risk of psychotropic drug (antidepressants, antipsychotics, and anxiolytics) use compared to matched comparators. The higher risk is transient, as the risk for HL patients was normalized to that of the background population 5 years into survivorship.

Study II revealed that parenthood rates in young relapse-free HL survivors are comparable to the rates of matched comparators. Moreover, no adverse effects on the born children were identified. The use of assisted reproduction techniques in higher in HL survivors, especially male HL survivors treated with BEACOPP [bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone].

Study III showed that non-Hodgkin lymphoma (NHL) patients have a higher risk of PD use compared to matched comparators. More aggressive subtypes of NHL have the highest risk. For all patients except those with indolent NHL, the risk is transient and normalized 5 years after NHL diagnosis. Risk of intentional self-harm and suicide is also higher in NHL patients.

Host

Department of Clinical Medicine, Aalborg University and Aalborg University Hospital

More information

https://aaudk.zoom.us/j/69091683604

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