Research

PhD defense by Ditte Nymark Hansen

The Department of Clinical Medicine, Aalborg University and Aalborg University Hospital are pleased to invite to PhD defense by MD, Ditte Nymark Hansen, who will defend the thesis entitled: Low birthweight - definition, screening and prediction

Time

03.12.2021 kl. 13.00 - 16.00

Description

The PhD defense will take place

Friday 3rd December, 2021 13:00

in the auditorium, Aalborg University Hospital Nord

and online at https://aaudk.zoom.us/j/61790084487

After the defense there will be held a reception. All are welcome.

 

Supervisors

Clinical Associate Professor Anne Nødgaard Sørensen, MD, PhD

Department of Clinical Medicine, Aalborg University, Denmark

Department of Obstetrics and Gynecology, Aalborg University Hospital, Denmark

Clinical Associate Professor Marianne Sinding, MD, PhD

Department of Clinical Medicine, Aalborg University, Denmark

Department of Obstetrics and Gynecology, Aalborg University Hospital, Denmark

Henriette Strøm Kahr, MD, PhD

Department of Obstetrics and Gynecology, Aarhus University Hospital, Denmark

David Alberg Peters, MSc, PhD

Department of Clinical Engineering, Central Denmark Region, Aarhus, Denmark

Professor Ole Bjarne Christiansen, MD, DMSc

Department of Clinical Medicine, Aalborg University, Denmark

Department of Obstetrics and Gynecology, Aalborg University Hospital, Denmark

Professor Niels Uldbjerg, MD, DMSc

Department of Obstetrics and Gynecology, Aarhus University Hospital, Denmark

 

Assessment Committee

Research Associate Professor Tine Dalsgaard Clausen, MD, PhD

Department of Obstetrics and Gynecology, Nordsjællands Hospital, Hillerød, University of Copenhagen, Denmark

Professor Lucy Chappell, MD, PhD

King’s College London, UK

Clinical Associate Professor Louise Arenholt, MD, PhD

Department of Obstetrics and Gynecology, Center for Clinical Research, North Denmark Regional Hospital, Aalborg University Denmark

 

 

About the PhD thesis

The definition of low birthweight (BW) varies worldwide, as different BW curves are used as references. Screening for low BW is an important part of the antenatal care, as low BW may be a result of fetal growth restriction due to placental dysfunction.

The aim of this project was to compare various definitions of low BW (Study I), to investigate the performance of the antenatal screening of small-for-gestational-age (SGA) (Study II) and to investigate the prediction of low BW and placental dysfunction using T2* weighted placental magnetic resonance imaging as a proxy of placental function (Study III).

Study I showed that the definition of low BW was markedly different when comparing a universal standard BW curve to the constructed Danish standard curve. Moreover, low BW was associated with an increased risk of adverse neonatal outcomes, although the majority of adverse outcomes occurred in normal-weighted pregnancies. The performance of the antenatal screening of SGA has improved over the last 20 years when investigated in a local clinical cohort (Study II). Antenatal identification of SGA increased the risk of obstetric interventions in both the SGA neonates as well as normal-weighted neonates. Additionally, Study III demonstrated that placental dysfunction was frequent in our cohort of suspected SGA pregnancies with normal fetal Doppler flows. T2* weighted placental MRI was a strong biomarker of placental dysfunction regardless of clinical manifestations such as low BW.

In conclusion, the antenatal detection of low BW is challenged by different reference curves and low sensitivity of the SGA screening. Moreover, fetal size alone does not perfectly reflect placental dysfunction. However, the first step to a greater understanding and more knowledge is acknowledging that placental dysfunction is more than just low BW.

Host

Department of Clinical Medicine, Aalborg University and Aalborg University Hospital

Address

Aalborg Sygehus Nord, Reberbansgade 15, 9000 Aalborg

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