Research

PhD defense by Rasmus Kapalu Broge Richelsen

The Department of Clinical Medicine, Aalborg University and Aalborg University Hospital are pleased to invite to PhD defense by MD, Rasmus Kapalu Broge Richelsen.

Time

04.12.2020 kl. 13.00 - 16.00

Description

Rasmus will defend the thesis entitled:

Community-onset bacteraemia and urinary tract infection with extended-spectrum b-lactamase-producing Escherichia coli and Klebsiella pneumoniae: risk and prognosis in a population-based study

The PhD defense will take place

Friday, December 4, 2020 at 13.00

Due to COVID-19 the PhD defense will be held online.
For registration please write an e-mail to Christina Elmer:inst.klinisk.phd@dcm.aau.dk no later than December 2, 2020.  

 

Supervisors

Professor Henrik Nielsen
Department of Infectious Diseases, Aalborg University Hospital
and Department of Clinical Medicine, Aalborg University, Aalborg, Denmark

Professor Henrik Carl Schønheyder
Department of Clinical Microbiology, Aalborg University Hospital
and Department of Clinical Medicine, Aalborg University, Aalborg, Denmark

Jesper Smit, MD, PhD
Department of Infectious Diseases
Aalborg University Hospital, Aalborg, Denmark


Assessment committee

Professor Lene Dreyer
Department of Rheumatology, Aalborg University Hospital
and Department of Clinical Medicine, Aalborg University, Aalborg, Denmark                                           

Professor Pontus Naucler
Department of Medicine Solna, Unit for Infectious Diseases
Karolinska Institutet, Stockholm, Sweden

Professor Niels Frimodt-Møller
Department of Clinical Microbiolog
Rigshospitalet, Copenhagen, Denmark

 

About the PhD thesis

The World Health Organization has named antibiotic resistance one of the biggest threats to global health. Escherichia coli and Klebsiella pneumoniae are the two major gram-negative bacteria causing community-onset urinary tract infection and bacteraemia. In the last two decades, an increasing proportion of E. coli and K. pneumoniae isolates capable of producing extended-spectrum b-lactamase (ESBL) has been observed throughout the world, rendering the bacteria resistant to most b-lactam antibiotics except carbapenems.

Data elucidating incidence, risk factors, and prognosis of community-onset ESBL-producing E. coli and K. pneumoniae infections from traditionally low-prevalence antibiotic resistance countries like Denmark is scarce. This information is important to improve our knowledge on these resistant bacteria and their relation to infections in humans. Moreover, such information contributes to better interventions that may serve to prevent antibiotic resistance, identify patients at risk, improve empirical antibiotic therapy and better the prognosis of patients suffering from these infections.

The thesis is based on four register-based studies. The first study elucidates the increase in community-onset ESBL E. coli and K. pneumoniae infections in the North Denmark Region from 2007 to 2017. Study II investigates risk factors of ESBL E. coli and K. pneumoniae bacteraemia, while Study III is a methodological study investigating the impact of the chosen methodology, when examining antibiotic use as a risk factor of ESBL-producing E. coli and K. pneumoniae bacteraemia. Finally, Study IV ascertains the prognostic impact of infections with these resistant bacteria.

Host

Department of Clinical Medicine, Aalborg University

Address

Online via Zoom

Registration Deadline

02.12.2020 kl. 15.00

Register at

inst.klinisk.phd@dcm.aau.dk

Events

See the list